Semaglutide Dosage Chart: Complete Guide (+FAQs)

Learn how the semaglutide dosage chart can help you take semaglutide correctly and achieve your weight loss goals.

Medically reviewed by Dr. Ruth Cohen,
Medical Director, Layla
Reviewed by
Dr. Ruth Cohen
Medical Director, Layla
Last Updated
July 17, 2024
8 clinical references

Semaglutide has gained popularity for its high efficacy in managing type 2 diabetes and obesity. Wegovy, a semaglutide brand, is FDA-approved for weight loss. Ozempic is another semaglutide brand that may be prescribed off-label for weight loss. However, following the appropriate dosage of semaglutide is important to maximize benefits and minimize side effects.

In this article, we will look at the role of semaglutide in weight loss, how the medication is dosed, and how you can maximize its benefits.

Semaglutide Weight Loss Dosage Chart Overview

The semaglutide treatment plan takes a structured approach with a stepwise increase in doses to achieve the best results. Here is how this medication is dosed for weight loss:


Week Dosage Volume (units) for injection
Weeks 1 - 4 0.25 mg (Starting dose) 10 units weekly
Weeks 5 - 8 0.5 mg 20 units weekly
Weeks 9 - 12 1 mg 40 units weekly
Weeks 13 - 16 1.7 mg 68 units weekly
Weeks 17+ 2.4 mg (Maximum dose) 96 units weekly

Starting Dose

Whether Ozempic or Wegovy, the ideal and approved starting dose of Semaglutide is 0.25 mg, injected once weekly for the first month. This initial dose is for initiating treatment and won't really control your blood sugar.

Gradual Increments

After the initial four weeks, the semaglutide dose may be increased to 0.5 mg weekly for one month. During this increment, semaglutide starts regulating blood sugar levels. The dose is increased the next month, and so on, until the ceiling dose is reached.

Maximum Dose

The maximum dose of Ozempic and Wegovy for you is 2.0 mg and 2.4 mg respectively once weekly. At this dose, most individuals are already enjoying the full benefits of Semaglutide.

Using a Semaglutide Chart to Lose Weight

Your healthcare provider can use a semaglutide weight loss dosage chart during your treatment to ensure you take the optimal dose for the best results.

The dosage chart serves as a guide on your weight loss journey with an appropriate starting dose and gradual increments monthly. Your healthcare provider can adjust the dosage chart based on your response to semaglutide and the potential for side effects.

While higher doses of semaglutide on the chart can cause more weight loss, it is important that you do not increase the dose without consulting your healthcare provider. 

Factors Influencing Dosage

The Importance of Medical Supervision

During your entire treatment with Semaglutide, it is essential that you maintain a close relationship with your healthcare provider. These professionals can help you achieve better results with your weight management. Your doctor can personalize your semaglutide dosage plan after evaluating you and running various tests.

Your healthcare provider might notice certain side effects early and adjust your semaglutide weight loss dosage chart accordingly. If you are not getting the optimal results, a medical professional can adjust your dosage plan.

The Impact of Other Health Conditions

Underlying health conditions can affect how your body responds to semaglutide. Some health disorders may even prevent you from using semaglutide. For example: 

  1. A history of medullary thyroid carcinoma (MTC)
  2. Multiple endocrine neoplasia type 2 (a type of endocrine tumor)
  3. A history of severe allergic reactions to semaglutide

Additionally, inform your doctor before getting pregnant. Your healthcare provider may counsel you on the possibility of stopping semaglutide before pregnancy.

What is Semaglutide?

Semaglutide is an anti-diabetic medication that has also been useful in weight management. It belongs to the class of drugs known as Glucagon-like peptide-1 (GLP-1) receptor agonists. There are three major brands of Semaglutide: Ozempic, Wegovy, and Rybelsus. Wegovy is the only FDA-approved brand for weight loss.

How Semaglutide Works for Weight Loss

Semaglutide is a GLP-1 receptor agonist. Thus, it regulates blood sugar by increasing insulin secretion. Additionally, semaglutide contributes to weight loss by:

  • Regulating appetite to reduce the amount of food you eat and
  • Reducing the time it takes for food to leave your stomach. This gives you a sense of fullness.

Using Semaglutide in the long term can help you manage your weight effectively.

Benefits of Semaglutide for Weight Loss

Semaglutide is highly effective in weight loss and has a number of advantages that positively impact weight loss. Studies show that Wegovy resulted in a 10% to 15% weight reduction over 68 weeks.

Reduced Appetite and Increased Fullness

Due to its actions on the GLP-1 receptor, semaglutide reduces hunger and gives a sense of fullness. This allows you to eat less food, reduces calories, and facilitates weight loss.

Glycemic Control and Reduced Cravings

Semaglutide slows down the emptying of food from your stomach, making you feel full and reduces cravings. By helping you maintain good glycemic control, semaglutide ensures your blood sugar does not crash, which may otherwise trigger unhealthy cravings.

Administering Semaglutide

Administering Semaglutide

How to Administer Injectable Semaglutide

Injectable semaglutide is administered subcutaneously (under your skin). You can inject it into the abdomen, thigh, and upper arm via a pen.

Proper Use and Storage of Semaglutide

Injection Technique and Frequency 

You administer semaglutide subcutaneously once a week into any of the sites mentioned above. You will need to administer the drug on the same day each week. You can use semaglutide at any time of the day, regardless of whether you have eaten. 

If you are injecting into the same body region weekly, it would be best to use a different injection site.

Storage Requirements

Semaglutide injectable comes in single-use pens that you must store appropriately to maintain efficacy and sterility. Before using a semaglutide pen for the first time, ensure you keep it refrigerated between 36F and 46F. After use, store the pen without the needle. Also, ensure you keep the pen's cap on if not in use and avoid direct sunlight or excessive heat. Also, do not use semaglutide if it is frozen.

Monitoring Progress and Dosage Adjustments

Regular Check-Ups and Follow-Ups

While on Semaglutide, it is important to visit your healthcare provider regularly. These professionals can assess your health and response to Semaglutide and offer advice on other lifestyle modifications that can augment your weight loss journey.

With regular follow-ups, your healthcare provider can address any concerns you have. These check-ups and follow-ups can be invaluable on your weight loss journey with semaglutide. 

Tracking Weight Loss and Other Health Markers

Monitoring health markers like your weight and blood sugar can give you a picture of your response to semaglutide. Also, pay attention to strange symptoms and do not hesitate to contact your healthcare provider.

Adjusting Dosages for Optimal Results

Your doctor can adjust your dosage based on your response to semaglutide to get the best results.

Potential Risks and Precautions

Semaglutide Risks and Precautions

Common Side Effects

Individuals using semaglutide can experience common side effects like nausea, diarrhea, vomiting, constipation, abdominal pain, and fatigue.

If you experience less common side effects, such as facial swelling or difficulty breathing, like those of a severe allergic reaction, contact your healthcare provider immediately.

Precautions and Contraindications

Individuals who have had a hypersensitivity reaction to all forms of Semaglutide should avoid the medication. Before starting semaglutide, ensure to discuss with your healthcare provider if you have conditions like depression, type 2 DM, renal disease, or pancreatic disease.

If you are on any chronic drug, inform your healthcare provider to prevent drug interactions with semaglutide. This includes other anti-diabetic medications like insulin.

Semaglutide is contraindicated in individuals with personal or family history of medullary thyroid carcinoma (MTC) and multiple endocrine neoplasia syndrome type 2 (MEN 2). 

Renal and Liver Dose Adjustments

There is no recommended dosage adjustment relating to the kidney or liver. If you have renal or hepatic diseases, discuss with your healthcare provider before commencing semaglutide.

What If You Miss a Dose?

If you miss a dose and it is more than two days before your next dose, then inject the missed dose as soon as you remember.

If you miss a dose less than two days before your next dose, skip the missed dose. Just wait and take your next dose at the scheduled time.

Conclusion

Semaglutide, a GLP-1 receptor agonist, offers a potential solution to your weight management. However, correct dosing and adherence to the semaglutide weight loss dosage chart are important to get the best results. Starting doses of semaglutide begin at 0.25 mg per week until a maximum dose of 2.4 mg per week.

Discuss with your healthcare provider if semaglutide is right for you and create a personalized dosage plan.

Frequently Asked Questions

How fast will I lose weight on semaglutide?

How fast weight loss occurs varies from person to person. Studies have shown that you may lose up to 5% of your body weight within four weeks of starting semaglutide. The same studies also show that you can expect to have lost about 16% of your body weight after 68 weeks of Semaglutide treatment.

Which is better, metformin or semaglutide?

Metformin and semaglutide are two different drugs with separate mechanisms of action. Both metformin and semaglutide are used to treat type 2 DM. However, semaglutide is FDA-approved for weight management. Hence, semaglutide is better than metformin for weight loss.

Is there a natural semaglutide?

No. Semaglutide is a synthetic medication that mimics GLP-1, a hormone found in humans. There is no natural source.

Can I quickly switch between semaglutide tablets and injections?

No. Although you can switch from semaglutide tablets to injections and vice versa, you must take a 7-day break before switching. Note that semaglutide's oral brand, Rybelsus, is not approved for weight loss.

Are There Side Effects Associated with High Doses of Semaglutide?

Yes. High doses of semaglutide can cause side effects such as diarrhea, vomiting, nausea, or constipation. Higher than prescribed doses can cause low blood sugar or dehydration. Rarely, high doses of semaglutide can cause pancreatitis. Follow the prescribed semaglutide dosage plan and contact your healthcare provider if you're experiencing any side effects.

Sources

  1. https://www.novo-pi.com/ozempic.pdf
  2. Wegovy® Dosing Schedule | Wegovy® (semaglutide) Injection 2.4 mg
  3. OZEMPIC (semaglutide) injection, for subcutaneous use (fda.gov)
  4. Semaglutide for weight loss - PMC (nih.gov)
  5. Effects of once‐weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity - PMC (nih.gov)
  6. Semaglutide Injection: MedlinePlus Drug Information
  7. Safety & Side Effects | Ozempic® (semaglutide) injection 0.5 mg, 1 mg, or 2 mg (novomedlink.com)
  8. Type 2 Diabetes Medicine | RYBELSUS® (semaglutide) tablets

Disclaimer

Off-Label Use: When discussing off-label uses, such as using Ozempic for weight loss, make it clear that this is not FDA-approved for that purpose. For example, you can add a disclaimer like: “While Ozempic is primarily approved for treating Type 2 diabetes, some healthcare providers may prescribe it off-label for weight loss. However, this use is not FDA-approved.”

Medical Advice Disclaimer: Clearly state that the article is for informational purposes only and not a substitute for professional medical advice. Encourage readers to consult with their healthcare provider before starting any new medication.

Tirzepatide: The New Challenger
Tirzepatide is relatively new to the market and works by activating both the GLP-1 and GIP receptors. This dual-action approach is theorized to offer more potent effects on weight loss and glucose control.
Advantages:
Early studies indicate that Tirzepatide may offer superior glucose-lowering effects and weight loss compared to GLP-1 agonists alone. The medication could potentially provide an improvement in treatment outcomes for individuals with type 2 diabetes, particularly those who are also focusing on weight loss as part of their treatment goals.
Considerations:
As a newer medication, Tirzepatide’s long-term safety profile is still being established. Patients may experience side effects similar to other medications in the GLP-1 class, and close monitoring by a healthcare provider is recommended.
Choosing the Right GLP-1 Medication with Layla
At Layla, we provide a comprehensive overview of the GLP-1 medication options available in our program, detailing the benefits and considerations of each to help you make an informed decision for diabetes management or weight loss.
Semaglutide
A widely chosen GLP-1 medication, Semaglutide boasts a high satisfaction rate among patients due to its convenience of once-weekly dosing and efficacy in reducing blood sugar levels and aiding weight loss. When selecting Semaglutide through Layla, consider how its dosing schedule and health benefits align with your lifestyle.
What makes Semaglutide a highly effective choice?
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Acts on biological factors that can prevent weight loss
Suppresses appetite & helps you feel fuller, longer
Helps control blood sugars

Can I feel confident in the safety of Semaglutide?
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3 MONTH STARTER PROGRAM
● Best value option
● Ideal for those commencing their weight loss journey
● Convenient billing method: $247 charged monthly
● Doses start at 0.25 mg/week, escalating to 2.5 mg/week (totaling 10 mg)
● Limited to one use per customer

MONTHLY PROGRAM
● $297 per month
● Available for customers starting at a higher dose or already on medication

How does the program work?
Caret

STEP 1: Place your order online and complete a medical intake form detailing your health and weight loss goals.

STEP 2: Connect with your physician through our HIPAA-compliant telehealth platform. No more waiting weeks or months for appointments.

STEP 3: Once approved, your prescription is sent to a pharmacy, which will deliver the medication straight to your door.

STEP 4: Ongoing Support. We regularly check in with you to ensure you're maximizing the benefits of our program. Our support team is available for chat, and you can message your doctor anytime with questions.

See available plans
Tirzepatide
Tirzepatide stands as a powerful GLP-1 medication alternative, particularly for those seeking an effective diabetes and weight management solution with a more spaced dosing regimen. Its administration through injections allows for flexible treatment planning tailored to individual needs.
What makes Tirzepatide a highly effective choice?
Caret

Acts on biological factors that can prevent weight loss
Suppresses appetite & helps you feel fuller, longer
Helps control blood sugars

Can I feel confident in the safety of Tirzepatide?
Caret

3 MONTH STARTER PROGRAM
● Best value option
● Ideal for those commencing their weight loss journey
● Convenient billing method: $247 charged monthly
● Doses start at 0.25 mg/week, escalating to 2.5 mg/week (totaling 10 mg)
● Limited to one use per customer

MONTHLY PROGRAM
● $297 per month
● Available for customers starting at a higher dose or already on medication

How does the program work?
Caret

STEP 1: Place your order online and complete a medical intake form detailing your health and weight loss goals.

STEP 2: Connect with your physician through our HIPAA-compliant telehealth platform. No more waiting weeks or months for appointments.

STEP 3: Once approved, your prescription is sent to a pharmacy, which will deliver the medication straight to your door.

STEP 4: Ongoing Support. We regularly check in with you to ensure you're maximizing the benefits of our program. Our support team is available for chat, and you can message your doctor anytime with questions.

See available plans

Unsure about the right treatment?

Our team can help. Answer a few quick questions about yourself, and we'll guide you to the most suitable treatment option.