How To Manage Fatigue On GLP-1 Medications

Learn effective strategies to manage fatigue associated with GLP-1 medications, including sleep, nutrition, exercise, and medical support.

Medically reviewed by Dr. Ruth Cohen,
Medical Director, Layla
Reviewed by
Dr. Ruth Cohen
Medical Director, Layla
Last Updated
February 6, 2025
8 clinical references

How To Manage Fatigue On GLP-1 Medications

Fatigue is a common side effect when starting GLP-1 medications like Semaglutide or Tirzepatide, impacting up to 40% of patients. Here’s how to manage it effectively:

  • Sleep: Stick to a consistent sleep schedule and create an ideal sleep environment (cool, dark, quiet).

  • Nutrition: Eat small, balanced meals with proteins, complex carbs, and healthy fats. Stay hydrated and avoid skipping meals.

  • Light Exercise: Start with short walks (10-15 minutes) to boost energy without overexertion.

  • Track Symptoms: Use apps to monitor your energy levels, sleep, and meal timing.

  • Consult a Doctor: Persistent fatigue may require adjusting your medication or checking for vitamin deficiencies (e.g., B12, Vitamin D, Iron).

If fatigue disrupts daily life, seek medical advice promptly. With the right lifestyle changes and support, most patients see improvements over time.

Fatigue with Wegovy, Ozempic, and Saxenda

Wegovy

Daily Habits to Fight Fatigue

Better Sleep Habits

Getting good sleep is key when you're on GLP-1 medications. Aim to keep your bedroom cool (around 60-67°F), dark, and quiet to create the perfect environment for restful sleep. Sticking to a regular sleep schedule can also help your body stay in sync.

While sleep is the starting point, what you eat also plays a big role in managing fatigue.

Eating for Energy

Choose smaller, balanced meals that include proteins, complex carbs, and healthy fats. This approach helps keep your energy steady and supports digestion, which is especially important when dealing with the metabolic effects of GLP-1 medications.

Timing your meals can also make a difference. Eating earlier in the day and more frequently can help maintain energy and reduce nausea, which can sometimes worsen fatigue [4].

Along with eating well, adding light physical activity to your routine can boost your energy even more.

Light Exercise Benefits

Staying active helps fight fatigue, but it's important to ease into exercise while on GLP-1 medications. Start with simple activities, like short 10-15 minute walks, especially after meals. These can help increase your energy without leaving you feeling drained [1].

The key is to find the right balance between movement and rest that works for your energy levels.

Medical Help for Fatigue

Talk to Your Doctor

If fatigue persists and interferes with your daily life, even after lifestyle changes, it’s time to consult your doctor. Be ready to share details like when the fatigue started, how long it’s lasted, and anything that seems to make it better or worse. Your doctor might suggest adjusting your GLP-1 medication dose or timing, but don’t make any changes without their approval.

Vitamin and Mineral Support

Fatigue during GLP-1 treatment can sometimes be linked to nutrient deficiencies. Here are some key ones to keep an eye on:

Nutrient Role and Signs of Deficiency
Vitamin B12 Supports energy; low levels cause fatigue
Vitamin D Affects muscle strength and mood
Iron Needed for oxygen transport; deficiency leads to weakness
NAD+ Helps energy production and recovery

Platforms like Join Layla offer access to treatments like B12 injections and NAD+ therapy, but always get proper testing before starting any supplements.

Signs to Get Medical Tests

Certain symptoms mean you should seek medical attention right away:

  • Extreme fatigue that disrupts your routine

  • Dizziness, chest pain, or trouble breathing

  • Noticeable mood swings or confusion

"Fatigue varies by individual, making it essential to clarify symptoms during medical evaluations." - Almandoz [1]

Your doctor might order blood tests to check for anemia, thyroid issues, or vitamin deficiencies. These tests can help determine if your fatigue is linked to GLP-1 medication or another underlying issue.

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Managing Daily Energy

Time Your Activities

Knowing how GLP-1 medications impact your daily energy can help you plan smarter. Your body's natural energy patterns play a big role in determining when you're most productive. Align your key activities with your peak energy hours for better results.

Time of Day Best Activities Energy Management Tips
Morning Peak Important meetings, exercise Take medication after breakfast
Mid-Day Routine tasks, light activities Schedule short breaks
Afternoon Dip Administrative work, rest periods Plan for a lighter workload
Evening Gentle activities, preparation Focus on recovery and relaxation

Save Your Energy

Managing your energy means planning ahead and taking breaks when needed. Breaking big tasks into smaller, manageable steps can help you stay on track without overexerting yourself.

Simple Ways to Conserve Energy:

  • Use meal prep services or delegate tasks to save time and energy.

  • Keep a water bottle handy to stay hydrated throughout the day.

  • Schedule short, regular breaks between activities to recharge.

"Fatigue means different things to different people. Whether it means low energy, low desire, or lack of pleasure in something, it's important to tease out through a thorough history of what it means to each person." - Almandoz [2]

Monitor Your Fatigue

Technology can be a great tool for understanding how GLP-1 medications affect your energy. Apps and trackers can reveal patterns and help you pinpoint what impacts your fatigue.

Tips for Tracking Energy Levels:

  • Log your sleep, activity, and meals using apps or fitness trackers.

  • Pay attention to how medication timing and environmental factors influence your energy.

It's worth noting that 20-40% of patients may experience side effects like fatigue when starting GLP-1 medications [1]. Recognizing these patterns can help you build strategies to maintain steady energy levels over time.

Building Long-Term Energy

Set Daily Schedules

Sticking to a consistent daily routine can help your body adjust to GLP-1 medications. Many patients find that regular schedules lead to fewer side effects and more stable energy levels [1]. Try aligning your routine with when you take your medication and your natural energy highs and lows. This approach can reduce fatigue and help you stay productive.

If you're dealing with ongoing fatigue, a more comprehensive strategy may be needed.

Handle Ongoing Fatigue

To tackle persistent fatigue, focus on stress management techniques like mindfulness, light physical activity, and staying hydrated [1]. Lowering stress can help reduce cortisol levels, which may ease feelings of exhaustion.

However, if these changes don't make a noticeable difference, it might be time to seek professional advice.

Get Help and Support

When fatigue persists, professional guidance becomes crucial. Healthcare providers can tailor your treatment plan to better suit your needs and how you respond to the medication.

Telehealth services like Join Layla offer personalized support for GLP-1 users, including help with managing side effects and adjusting medications. With expert advice, many patients see improvements over time, leading to better results [1].

It’s worth noting that 20-40% of patients experience side effects initially [1], but these often decrease with the right medical care and consistent habits.

Conclusion: Steps to Fight Fatigue

Main Points Review

Starting GLP-1 medications can lead to temporary fatigue for up to 40% of patients. However, this can often be managed with a few targeted strategies, such as maintaining consistent sleep habits, eating a well-balanced diet, engaging in light physical activity, and seeking regular medical advice to fine-tune your treatment plan.

It's important to understand that fatigue is temporary and varies from person to person. An individualized approach, tailored to your unique lifestyle, habits, and treatment response, is key to managing these symptoms effectively.

Next Steps

To start addressing fatigue, focus on tracking your symptoms and working closely with your healthcare provider. Here are some practical steps to consider:

  • Monitor your daily fatigue levels and share this information with your doctor for personalized adjustments.

  • Stay hydrated and ensure your meals are nutritionally balanced.

  • Stick to regular sleep schedules and incorporate gentle exercise into your routine.

If fatigue persists despite these efforts, consulting your healthcare provider is crucial for revisiting your treatment plan and ensuring it aligns with your needs [1][3].

FAQs

How to manage fatigue from Wegovy?

Dealing with fatigue while using Wegovy (semaglutide) involves focusing on habits that help maintain consistent energy levels throughout the day.

Nutrition and Hydration
Stick to small, balanced meals every 3-4 hours, emphasizing protein and complex carbs. Drink 8-10 glasses of water daily to stay hydrated, and try to avoid high-fat or spicy foods, as they can make dehydration worse [1][4].

Activity Management
Incorporate light activities like short 10-15 minute walks. Plan your most important tasks during times when you feel most energized and take brief breaks to prevent overdoing it.

If fatigue becomes severe, interferes with daily life, or comes with unusual symptoms like dizziness or weakness, reach out to your healthcare provider.

It's worth noting that up to 40% of patients may feel temporary fatigue when starting GLP-1 medications. However, this often gets better as the body adjusts [1][2]. Regular communication with your healthcare provider can help fine-tune your treatment plan and address side effects effectively.

These tips build on general methods for managing GLP-1-related fatigue and can be adjusted to fit your personal needs, helping you maintain better energy levels while on Wegovy.

Tirzepatide: The New Challenger
Tirzepatide is relatively new to the market and works by activating both the GLP-1 and GIP receptors. This dual-action approach is theorized to offer more potent effects on weight loss and glucose control.
Advantages:
Early studies indicate that Tirzepatide may offer superior glucose-lowering effects and weight loss compared to GLP-1 agonists alone. The medication could potentially provide an improvement in treatment outcomes for individuals with type 2 diabetes, particularly those who are also focusing on weight loss as part of their treatment goals.
Considerations:
As a newer medication, Tirzepatide’s long-term safety profile is still being established. Patients may experience side effects similar to other medications in the GLP-1 class, and close monitoring by a healthcare provider is recommended.
Choosing the Right GLP-1 Medication with Layla
At Layla, we provide a comprehensive overview of the GLP-1 medication options available in our program, detailing the benefits and considerations of each to help you make an informed decision for diabetes management or weight loss.
Semaglutide
A widely chosen GLP-1 medication, Semaglutide boasts a high satisfaction rate among patients due to its convenience of once-weekly dosing and efficacy in reducing blood sugar levels and aiding weight loss. When selecting Semaglutide through Layla, consider how its dosing schedule and health benefits align with your lifestyle.
What makes Semaglutide a highly effective choice?
Caret

Acts on biological factors that can prevent weight loss
Suppresses appetite & helps you feel fuller, longer
Helps control blood sugars

Can I feel confident in the safety of Semaglutide?
Caret

3 MONTH STARTER PROGRAM
● Best value option
● Ideal for those commencing their weight loss journey
● Convenient billing method: $247 charged monthly
● Doses start at 0.25 mg/week, escalating to 2.5 mg/week (totaling 10 mg)
● Limited to one use per customer

MONTHLY PROGRAM
● $297 per month
● Available for customers starting at a higher dose or already on medication

How does the program work?
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STEP 1: Place your order online and complete a medical intake form detailing your health and weight loss goals.

STEP 2: Connect with your physician through our HIPAA-compliant telehealth platform. No more waiting weeks or months for appointments.

STEP 3: Once approved, your prescription is sent to a pharmacy, which will deliver the medication straight to your door.

STEP 4: Ongoing Support. We regularly check in with you to ensure you're maximizing the benefits of our program. Our support team is available for chat, and you can message your doctor anytime with questions.

See available plans
Tirzepatide
Tirzepatide stands as a powerful GLP-1 medication alternative, particularly for those seeking an effective diabetes and weight management solution with a more spaced dosing regimen. Its administration through injections allows for flexible treatment planning tailored to individual needs.
What makes Tirzepatide a highly effective choice?
Caret

Acts on biological factors that can prevent weight loss
Suppresses appetite & helps you feel fuller, longer
Helps control blood sugars

Can I feel confident in the safety of Tirzepatide?
Caret

3 MONTH STARTER PROGRAM
● Best value option
● Ideal for those commencing their weight loss journey
● Convenient billing method: $247 charged monthly
● Doses start at 0.25 mg/week, escalating to 2.5 mg/week (totaling 10 mg)
● Limited to one use per customer

MONTHLY PROGRAM
● $297 per month
● Available for customers starting at a higher dose or already on medication

How does the program work?
Caret

STEP 1: Place your order online and complete a medical intake form detailing your health and weight loss goals.

STEP 2: Connect with your physician through our HIPAA-compliant telehealth platform. No more waiting weeks or months for appointments.

STEP 3: Once approved, your prescription is sent to a pharmacy, which will deliver the medication straight to your door.

STEP 4: Ongoing Support. We regularly check in with you to ensure you're maximizing the benefits of our program. Our support team is available for chat, and you can message your doctor anytime with questions.

See available plans

Unsure about the right treatment?

Our team can help. Answer a few quick questions about yourself, and we'll guide you to the most suitable treatment option.