Does Semaglutide (Ozempic) Make You Tired? Research (+ Tips)

Semaglutide (Ozempic) is a potent weight-loss medication. Discover the connection between Semaglutide and fatigue and how to manage this tiredness.

Medically reviewed by Dr. Ruth Cohen,
Medical Director, Layla
Reviewed by
Dr. Ruth Cohen
Medical Director, Layla
Last Updated
July 17, 2024
8 clinical references

Does Semaglutide (Ozempic) Make You Tired? Research (+ Tips)

Semaglutide is an anti-diabetic medication that has also gained popularity for its high efficacy in treating obesity. Ozempic, a brand of semaglutide, is an injectable mainly used in managing Type 2 diabetes. However, Ozempic is also useful in weight management and can be prescribed off-label. As with many medications, users may experience some side effects. One of the common side effects is fatigue. 

In this article, we will have a closer look at why you may feel tired while taking semaglutide and how to manage this tiredness effectively.

What is the Connection Between Semaglutide and Fatigue?

Semaglutide has various effects on the body that might initially make you feel more tired. To better understand the connection between Semaglutide and fatigue, we must first explore what Semaglutide is and how it works in the body.

What is Semaglutide?

Semaglutide is an antidiabetic medication that lowers blood sugar and helps with weight loss. It belongs to a class of drugs called Glucagon-like peptide-1 (GLP-1) receptor agonists.

Semaglutide is of immense value in managing individuals with Type 2 Diabetes Mellitus. This medication has also garnered attention as it is one of the few FDA-approved drugs for managing obesity.

Semaglutide is available in three major brands: Ozempic, Rybelsus, and Wegovy. Doctors use Ozempic and Rybelsus to treat Type 2 diabetes, while Wegovy injection is approved for weight loss management.

Common Side Effects of Semaglutide

Individuals on semaglutide have reported various side effects. Here are some of the common ones:

  1. Nausea
  2. Low blood sugar, especially in people with type 2 diabetes
  3. Vomiting
  4. Diarrhea 
  5. Constipation
  6. Fatigue
  7. Stomach pain
  8. Headache
  9. Burping
  10. Heartburn

Individuals on Ozempic may experience less common side effects like injection site reactions and allergic reactions.

How Semaglutide Works in the Body

Semaglutide is a GLP-1 receptor agonist that increases the release of insulin. This drug also reduces how your liver releases glucose into the blood by inhibiting a hormone called glucagon. The increase in insulin and decrease in glucagon lowers high sugar levels in the blood and is particularly useful in Type 2 diabetes.

Additionally, semaglutide gives you a sense of fullness by reducing appetite and slowing down digestion in the stomach. This effect is beneficial in Type 2 diabetes and has shown high efficacy in weight management.

5 Reasons for Fatigue During Semaglutide Treatment

Fatigue During Semaglutide Treatment

We have seen how semaglutide works and some of the side effects of this drug. Fatigue is one of the common side effects that individuals on semaglutide may experience. This raises the question: Why does semaglutide make you tired? Read on to find out the reasons behind this fatigue.

  1. The Body's Adjustment Period

As with many medications, it might take a while for the body to adjust to using them. Ozempic causes various hormonal changes that your body needs to adjust to. This initial adjustment can explain why semaglutide makes you tired. With time, the body fully adapts and the feelings of tiredness begin to diminish.

  1. Blood Sugar Level Fluctuations

Semaglutide is known for lowering blood sugar, an effect that is helpful in managing diabetes. Low blood sugar can cause symptoms like fatigue, dizziness, and excessive sweating. However, as your body adapts to Ozempic's sugar-lowering effect, you will notice an increase in your energy levels.

  1. Impact on Appetite and Nutrition

Semaglutide works by suppressing appetite and giving you a feeling of fullness. This means you consume fewer calories and have less energy, making you feel fatigued. However, your body soon adjusts its demands and as time passes, you feel less tired even though the amount of food you eat has decreased.

  1. Physical Activity and Weight Loss

Weight loss is one of the well-known effects of semaglutide. However, rapid weight loss can lead to feelings of fatigue. Because of the initial imbalance between energy demand and supply while using Ozempic, engaging in physical activity can make you feel tired since your body requires more energy. The good news is that the tiredness from physical activity is transient and should not last more than a few weeks.

  1. Individual Variability in Response

As with any other drug, different individuals have varying responses to semaglutide. Some people experience fatigue while others do not. One study showed that only 6.3% of the participants experienced tiredness from semaglutide.

Managing Fatigue from Semaglutide

Fatigue from Semaglutide

The fatigue you may experience while using semaglutide is usually temporary. Does this mean you cannot do anything about this? Absolutely not! There are various ways you can cope with this tiredness while your body adjusts to semaglutide.

7 Tips for Reducing Fatigue

Here are seven tips that can help you deal with fatigue while on semaglutide:

  1. Stay Hydrated

Drinking plenty of water throughout the day while taking semaglutide is important. This reduces fatigue, as dehydration can make you feel more tired. Aim to drink at least 7 to 8 glasses of water daily.

  1. Improve Sleep Quality

Maintaining good sleep hygiene is very important. Having a good night's rest of six to eight hours will go a long way in reducing any tiredness you might experience from semaglutide. Getting enough sleep will also allow your body to adjust to Ozempic faster.

  1. Focus on Balanced Nutrition

While Ozempic can reduce your appetite and make you feel full, eating a balanced diet during meals can be helpful. A balanced diet ensures that your body gets the necessary nutrients and helps you adapt to eating less food, which can reduce feelings of fatigue.

  1. Get Regular Exercise

You can incorporate some exercise into your daily life to help reduce fatigue and enhance the weight loss effects of semaglutide. Regular exercise improves oxygen delivery to your muscles, helps you sleep better, and reduces overall tiredness.

  1. Ensure Regular Bowel Movements

Ozempic can make you constipated and cause your body to absorb less nutrients, leaving you tired. Moving bowels regularly can reduce fatigue. You can add fiber supplements to your diet to relieve constipation.

  1. Take B12 Supplements

Semaglutide can slow down the absorption of Vitamin B12 in the gut, which can cause low energy. If you feel fatigued after using semaglutide, taking B12 supplements after talking to your doctor can help you reduce that tiredness.

  1. Check for Drug Interactions

It is important to be cautious about drug interactions when using Ozempic with certain medications like Metformin or blood pressure drugs like metoprolol. This interaction could exacerbate feelings of fatigue. Check in with your healthcare provider if you're using other drugs alongside semaglutide.

Adjusting Dosage and Timing

If semaglutide makes you tired, your healthcare provider can adjust the dose over time. Your doctor can also suggest changing the time of the day you take semaglutide.

When to Seek Medical Advice

Ensure that you stay connected with your healthcare provider while using semaglutide. If you have persistent fatigue or tiredness disrupting your routine activities, seek medical advice. 

Furthermore, contact your doctor if you notice other side effects, like constant dizziness or a change in your heartbeat.

Long-Term Outlook and Well-Being While Using Semaglutide

Well Being with Semaglutide

Evaluating Fatigue Over Time

It is important to assess how semaglutide affects fatigue over time. Typically, the initial feelings of fatigue reduce over time as the body adjusts to the medication. If you continue feeling tired, do not hesitate to contact your healthcare provider.

Monitoring Overall Health

You should monitor your overall health and your blood sugar levels and watch out for any symptoms you might have. If you notice any strange symptoms, seek medical advice immediately.

Regular Check-ups with Healthcare Providers

Regular visits to your healthcare provider are important during your treatment with semaglutide. Communicating with them for clinical evaluations and tests is vital to ensure that you maintain good health. Your healthcare provider can evaluate how you are responding to semaglutide and address any concerns you may have.

Conclusion

Semaglutide is a drug that lowers blood sugar. Ozempic is an injectable semaglutide used to manage type 2 diabetes. Some individuals feel more tired on semaglutide, especially during the first few weeks. However, this fatigue is usually temporary, and the body later adapts.

Staying hydrated, eating well, and getting enough sleep are vital to reducing fatigue from Ozempic. Remember that regular check-ups and communicating with your healthcare provider will go a long way in giving you the best experience while on Ozempic.

Frequently Asked Questions

Why can't you drink on semaglutide?

Although drinking controlled amounts of alcohol may not cause harm, it is not recommended to drink while using semaglutide. Semaglutide lowers blood sugar; alcohol does the same. This can potentially lead to dangerous reductions in blood sugar. Discuss with your healthcare provider the amount of alcohol that is safe for you to drink.

What happens if you eat sugar while taking Ozempic?

Occasional consumption of sugar may not significantly affect you while taking Ozempic. However, excessive sugar consumption leads to spikes in your blood sugar and reduces the effectiveness of Ozempic. Additionally, eating high amounts of sugar can make you gain weight.

How to increase energy on semaglutide?

Some individuals experience low energy and fatigue while on semaglutide. Staying hydrated, eating a balanced diet, and getting good sleep are some ways to increase your energy while on this drug.

Can I eat pizza while on semaglutide?

It is best to avoid pizza while on Ozempic. However, you should know that food like pizza contains high amounts of fat and calories. This can work against individuals using semaglutide for weight loss. Also, individuals with Type 2 DM should strive to reduce their consumption of pizza and other fat-rich foods. 

What is a natural replacement for Ozempic?

Some people may consider Ozempic expensive. Various natural substitutes like berberine and psyllium husk have been proposed as alternatives to Ozempic. However, studies have shown that these natural products are less effective than Ozempic.

Is Metamucil like Ozempic?

No! While Ozempic regulates blood sugar, Metamucil is a fiber supplement that functions as a laxative.

Sources

  1. https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/medications-containing-semaglutide-marketed-type-2-diabetes-or-weight-loss
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272494/
  3. https://www.ncbi.nlm.nih.gov/books/NBK603723/
  4. https://www.drugs.com/food-interactions/semaglutide,ozempic.html
  5. https://diabetes.org/food-nutrition/reading-food-labels/fats
  6. https://www.metamucil.com/en-us
  7. Ozempic PI (novo-pi.com)
  8. Ozempic for Weight Loss: Side Effects, Cost, and More (healthline.com)
  9. Ozempic subcutaneous: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD

Disclaimer

Off-Label Use: When discussing off-label uses, such as using Ozempic for weight loss, make it clear that this is not FDA-approved for that purpose. For example, you can add a disclaimer like: “While Ozempic is primarily approved for treating Type 2 diabetes, some healthcare providers may prescribe it off-label for weight loss. However, this use is not FDA-approved.”

Medical Advice Disclaimer: Clearly state that the article is for informational purposes only and not a substitute for professional medical advice. Encourage readers to consult with their healthcare provider before starting any new medication.

Tirzepatide: The New Challenger
Tirzepatide is relatively new to the market and works by activating both the GLP-1 and GIP receptors. This dual-action approach is theorized to offer more potent effects on weight loss and glucose control.
Advantages:
Early studies indicate that Tirzepatide may offer superior glucose-lowering effects and weight loss compared to GLP-1 agonists alone. The medication could potentially provide an improvement in treatment outcomes for individuals with type 2 diabetes, particularly those who are also focusing on weight loss as part of their treatment goals.
Considerations:
As a newer medication, Tirzepatide’s long-term safety profile is still being established. Patients may experience side effects similar to other medications in the GLP-1 class, and close monitoring by a healthcare provider is recommended.
Choosing the Right GLP-1 Medication with Layla
At Layla, we provide a comprehensive overview of the GLP-1 medication options available in our program, detailing the benefits and considerations of each to help you make an informed decision for diabetes management or weight loss.
Semaglutide
A widely chosen GLP-1 medication, Semaglutide boasts a high satisfaction rate among patients due to its convenience of once-weekly dosing and efficacy in reducing blood sugar levels and aiding weight loss. When selecting Semaglutide through Layla, consider how its dosing schedule and health benefits align with your lifestyle.
What makes Semaglutide a highly effective choice?
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Acts on biological factors that can prevent weight loss
Suppresses appetite & helps you feel fuller, longer
Helps control blood sugars

Can I feel confident in the safety of Semaglutide?
Caret

3 MONTH STARTER PROGRAM
● Best value option
● Ideal for those commencing their weight loss journey
● Convenient billing method: $247 charged monthly
● Doses start at 0.25 mg/week, escalating to 2.5 mg/week (totaling 10 mg)
● Limited to one use per customer

MONTHLY PROGRAM
● $297 per month
● Available for customers starting at a higher dose or already on medication

How does the program work?
Caret

STEP 1: Place your order online and complete a medical intake form detailing your health and weight loss goals.

STEP 2: Connect with your physician through our HIPAA-compliant telehealth platform. No more waiting weeks or months for appointments.

STEP 3: Once approved, your prescription is sent to a pharmacy, which will deliver the medication straight to your door.

STEP 4: Ongoing Support. We regularly check in with you to ensure you're maximizing the benefits of our program. Our support team is available for chat, and you can message your doctor anytime with questions.

See available plans
Tirzepatide
Tirzepatide stands as a powerful GLP-1 medication alternative, particularly for those seeking an effective diabetes and weight management solution with a more spaced dosing regimen. Its administration through injections allows for flexible treatment planning tailored to individual needs.
What makes Tirzepatide a highly effective choice?
Caret

Acts on biological factors that can prevent weight loss
Suppresses appetite & helps you feel fuller, longer
Helps control blood sugars

Can I feel confident in the safety of Tirzepatide?
Caret

3 MONTH STARTER PROGRAM
● Best value option
● Ideal for those commencing their weight loss journey
● Convenient billing method: $247 charged monthly
● Doses start at 0.25 mg/week, escalating to 2.5 mg/week (totaling 10 mg)
● Limited to one use per customer

MONTHLY PROGRAM
● $297 per month
● Available for customers starting at a higher dose or already on medication

How does the program work?
Caret

STEP 1: Place your order online and complete a medical intake form detailing your health and weight loss goals.

STEP 2: Connect with your physician through our HIPAA-compliant telehealth platform. No more waiting weeks or months for appointments.

STEP 3: Once approved, your prescription is sent to a pharmacy, which will deliver the medication straight to your door.

STEP 4: Ongoing Support. We regularly check in with you to ensure you're maximizing the benefits of our program. Our support team is available for chat, and you can message your doctor anytime with questions.

See available plans

Unsure about the right treatment?

Our team can help. Answer a few quick questions about yourself, and we'll guide you to the most suitable treatment option.