Best Weight Loss Injections of 2024

Looking for the best weight loss injections in 2024? Discover the best injectable options for your weight loss journey from this detailed list.

Medically reviewed by Dr. Ruth Cohen,
Medical Director, Layla
Reviewed by
Dr. Ruth Cohen
Medical Director, Layla
Last Updated
July 17, 2024
8 clinical references

Best Weight Loss Injections of 2024

Are you trying to lose weight and are exploring various weight loss options? You are not alone. Gone are the days when diet and exercise were the only solutions to losing weight. Several weight loss medications are available in the pharmaceutical market today. From Wegovy to Mounjaro, weight loss injections have shown high efficacy in managing obesity.

In this article, we will highlight the best weight loss injections, their cost, and factors influencing the choice of drug.

Key Takeaways

  • The three FDA-approved injections for weight loss are Wegovy, Saxenda, and Zepbound.
  • The cost of weight loss injections varies and may not be covered by your insurance.
  • Keep an open communication with your healthcare provider to obtain the best results from weight loss injections.

What Are the Top Weight Loss Injections?

The available weight loss injections were initially used in treating type 2 diabetes before finding usefulness in weight loss. The top weight loss injections that stand out are:

  • Semaglutide: Wegovy and Ozempic
  • Liraglutide: Saxenda and Victoza
  • Tirzepatide: Zepbound and Mounjaro 

Semaglutide

Semaglutide is a well-known medication for managing type diabetes and obesity. Wegovy, a brand of semaglutide, is one of the FDA-approved injections for managing obesity. Ozempic, the other injectable brand of semaglutide, is used mainly in treating Type 2 diabetes. However, Ozempic can be prescribed off-label for weight loss. 

Semaglutide is a glucagon-like peptide receptor 1 (GLP-1) receptor agonist that lowers blood sugar. This medication has been useful in weight loss by reducing appetite, giving a sense of fullness, and slowing down stomach emptying. 

While Wegovy and Ozempic can help manage weight, their efficacy is not the same. Clinical trials have shown that treatment with Wegovy can result in up to 15% reduction in body weight after 68 weeks. Over the same period, the maximum dose of Ozempic only caused a 7% reduction in body weight.

Typically, Ozempic and Wegovy start at 0.5 mg once weekly for the first month. After that, the dosages gradually increase every month until a maximum dose of 2.4 mg for Wegovy and 2.0 mg for Ozempic.

Common side effects of semaglutide include nausea, vomiting, abdominal pain, diarrhea, constipation, fatigue, and low blood sugar.

Liraglutide

Liraglutide is similar to semaglutide and helps manage type 2 DM and weight loss. This medication comes in two brands: Saxenda and Victoza. Victoza was initially approved for treating type 2 diabetes until its weight loss effects were noticed. Then, Saxenda, a higher-dose brand, became FDA-approved for weight loss.

Liraglutide is a GLP-1 receptor agonist that works similarly to semaglutide. Liraglutide facilitates weight loss by increasing insulin secretion, reducing appetite, and slowing gastric emptying. 

Studies have shown that individuals on Saxenda can expect about 5% to 10% weight loss over one year.

Saxenda and Victoza have similar starting doses at 0.6 mg daily. The dosages gradually increase until a maximum of 1.8 mg for Victoza and 3.0 mg for Saxenda. Hence, Saxenda is better for weight management than Victoza.

Common side effects of Saxenda include gastrointestinal symptoms like nausea, vomiting, diarrhea, and constipation.

Tirzepatide

Tirzepatide is a relatively newer drug on this list, approved in 2022 for managing type 2 diabetes under the brand name Mounjaro. Shortly after, tirzepatide became FDA-approved for weight management under the brand name Zepbound.

Tirzepatide has dual actions because it mimics GLP-1 and is also a glucose-dependent insulinotropic polypeptide (GIP) receptor agonist. This unique combination makes tirzepatide potentially more effective at weight management than any other drug on this list.

Zepbound

Zepbound is a brand of tirzepatide approved for weight loss. This drug is highly efficacious in helping individuals lose weight.

The starting dosage of Zepbound is 2.5 mg once a week for the first month. The dose is then increased every four weeks until a maximum of 15 mg once a week.

A study was done to showcase the efficacy of tirzepatide in weight management. This study showed that 57% of individuals on Zepbound had more than a 20% reduction in body weight after 72 weeks of treatment.

Common side effects of Zepbound include nausea, vomiting, diarrhea, stomach pain, and constipation. Most of these side effects resolve as your body adjusts to the drug.

Mounjaro

Mounjaro contains tirzepatide as its active ingredient. This brand is mainly used to treat type 2 DM. It is not FDA-approved for weight loss. However, your healthcare provider may prescribe it off-label for you.

Like Zepbound, the starting dose of Mounjaro is 2.5 mg once a week with gradual increments until a maximum of 15mg weekly.

A clinical trial conducted in 2023 studied the efficacy of Mounjaro in weight loss over 72 weeks. The study recorded an average of 24.3% reduction in weight when Mounjaro is combined with lifestyle modifications.

Factors That Affect Choice of A Weight Loss Injection

Weight Loss Injection

Your healthcare provider will assess you and consider several factors before prescribing the best weight loss injection for you. Some of these factors include:

  • Your age
  • Your body mass index (BMI)
  • Underlying conditions
  • Potential side effects and how you can tolerate them.

Also, the costs of weight loss injections vary. For instance, your insurance may only cover FDA-approved injectables for weight loss, like Wegovy, Zepbound, or Saxenda.

Cost of Weight Loss Injections

Weight loss injections can be expensive, and the overall cost can vary depending on factors like your location or insurance coverage. Here's an estimate of how much each drug costs: 

  • Wegovy: Around $1430 for a one-month supply
  • Ozempic: Around $1030 for a one-month supply
  • Saxenda: Around $1430 for a one-month supply 
  • Victoza: Around $582 for a one-month supply
  • Zepbound: Around $1126 for a month's supply
  • Mounjaro: Around $1135 for a month's supply

Remember that the prices above are estimates and may vary based on pharmacies and insurance coverage. Discuss with your healthcare provider whether your insurance covers these weight loss medications.

Safety and Monitoring

Weight Loss Monitoring

The Importance of Medical Supervision

It is best for you to communicate openly with your healthcare provider. Your doctor can assess your progress on these injections for weight loss and provide adjustments in dosage. Besides, healthcare professionals can identify budding side effects and prevent them from fully manifesting.

Regular Check-Ups

While on any of these medications, adhere to the appointments set by your healthcare provider. Your doctor can evaluate you clinically, run various tests, and assess your overall health. Also, pay attention to your blood sugar levels, how fast your heart beats, and any strange symptoms that may pop up.

Conclusion

There are three FDA-approved injectables for weight loss: Wegovy, Zepbound, and Saxenda. Combined with lifestyle changes, these medications offer promising solutions for weight management. Consult your healthcare provider to help choose the best weight loss injection for you.

Frequently Asked Questions

How quickly will I lose weight with injections?

The rate of weight loss with infections varies from person to person. Studies show that you can expect up to a 15% reduction in weight after 68 weeks of treatment with drugs like Wegovy. Note that factors like diet and physical activity can affect the rate at which you lose weight.

Are weight loss injections safe for long-term use?

Generally, weight loss injections are safe for use over long periods. As with most medications, weight loss injections have side effects that gradually reduce as time goes on. Studies have shown the effectiveness of long-term use of weight loss medications. 

Why are weight loss injections so expensive?

Weight loss Injections are expensive because they are sold under brand names. Generic versions are not yet available. Some of these medications may also not be covered by your insurance. You can look for companies that offer coupons or patient assistance programs to help you reduce the cost.

Sources

  1. https://www.ozempic.com/
  2. https://www.wegovy.com/
  3. https://www.ncbi.nlm.nih.gov/books/NBK551568/#:~:text=Glucagon%2Dlike%20peptide%2D1%20
  4. https://www.nejm.org/doi/full/10.1056/NEJMoa2032183
  5. https://www.saxenda.com/about-saxenda/how-it-works.html
  6. https://www.victoza.com/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358074/#osp484-bib-0003
  8. https://www.fda.gov/news-events/press-announcements/fda-approves-new-medication-chronic-weight-management
  9. https://pubmed.ncbi.nlm.nih.gov/33325008/
  10. https://www.nejm.org/doi/full/10.1056/NEJMoa2206038
  11. https://www.nature.com/articles/s41591-023-02597-w
  12. https://www.drugs.com/price-guide

Disclaimer

Off-Label Use: When discussing off-label uses, such as using Ozempic for weight loss, make it clear that this is not FDA-approved for that purpose. For example, you can add a disclaimer like: “While Ozempic is primarily approved for treating Type 2 diabetes, some healthcare providers may prescribe it off-label for weight loss. However, this use is not FDA-approved.”

Medical Advice Disclaimer: Clearly state that the article is for informational purposes only and not a substitute for professional medical advice. Encourage readers to consult with their healthcare provider before starting any new medication.

Tirzepatide: The New Challenger
Tirzepatide is relatively new to the market and works by activating both the GLP-1 and GIP receptors. This dual-action approach is theorized to offer more potent effects on weight loss and glucose control.
Advantages:
Early studies indicate that Tirzepatide may offer superior glucose-lowering effects and weight loss compared to GLP-1 agonists alone. The medication could potentially provide an improvement in treatment outcomes for individuals with type 2 diabetes, particularly those who are also focusing on weight loss as part of their treatment goals.
Considerations:
As a newer medication, Tirzepatide’s long-term safety profile is still being established. Patients may experience side effects similar to other medications in the GLP-1 class, and close monitoring by a healthcare provider is recommended.
Choosing the Right GLP-1 Medication with Layla
At Layla, we provide a comprehensive overview of the GLP-1 medication options available in our program, detailing the benefits and considerations of each to help you make an informed decision for diabetes management or weight loss.
Semaglutide
A widely chosen GLP-1 medication, Semaglutide boasts a high satisfaction rate among patients due to its convenience of once-weekly dosing and efficacy in reducing blood sugar levels and aiding weight loss. When selecting Semaglutide through Layla, consider how its dosing schedule and health benefits align with your lifestyle.
What makes Semaglutide a highly effective choice?
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Acts on biological factors that can prevent weight loss
Suppresses appetite & helps you feel fuller, longer
Helps control blood sugars

Can I feel confident in the safety of Semaglutide?
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3 MONTH STARTER PROGRAM
● Best value option
● Ideal for those commencing their weight loss journey
● Convenient billing method: $247 charged monthly
● Doses start at 0.25 mg/week, escalating to 2.5 mg/week (totaling 10 mg)
● Limited to one use per customer

MONTHLY PROGRAM
● $297 per month
● Available for customers starting at a higher dose or already on medication

How does the program work?
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STEP 1: Place your order online and complete a medical intake form detailing your health and weight loss goals.

STEP 2: Connect with your physician through our HIPAA-compliant telehealth platform. No more waiting weeks or months for appointments.

STEP 3: Once approved, your prescription is sent to a pharmacy, which will deliver the medication straight to your door.

STEP 4: Ongoing Support. We regularly check in with you to ensure you're maximizing the benefits of our program. Our support team is available for chat, and you can message your doctor anytime with questions.

See available plans
Tirzepatide
Tirzepatide stands as a powerful GLP-1 medication alternative, particularly for those seeking an effective diabetes and weight management solution with a more spaced dosing regimen. Its administration through injections allows for flexible treatment planning tailored to individual needs.
What makes Tirzepatide a highly effective choice?
Caret

Acts on biological factors that can prevent weight loss
Suppresses appetite & helps you feel fuller, longer
Helps control blood sugars

Can I feel confident in the safety of Tirzepatide?
Caret

3 MONTH STARTER PROGRAM
● Best value option
● Ideal for those commencing their weight loss journey
● Convenient billing method: $247 charged monthly
● Doses start at 0.25 mg/week, escalating to 2.5 mg/week (totaling 10 mg)
● Limited to one use per customer

MONTHLY PROGRAM
● $297 per month
● Available for customers starting at a higher dose or already on medication

How does the program work?
Caret

STEP 1: Place your order online and complete a medical intake form detailing your health and weight loss goals.

STEP 2: Connect with your physician through our HIPAA-compliant telehealth platform. No more waiting weeks or months for appointments.

STEP 3: Once approved, your prescription is sent to a pharmacy, which will deliver the medication straight to your door.

STEP 4: Ongoing Support. We regularly check in with you to ensure you're maximizing the benefits of our program. Our support team is available for chat, and you can message your doctor anytime with questions.

See available plans

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Our team can help. Answer a few quick questions about yourself, and we'll guide you to the most suitable treatment option.